CD31 mismatching affects marrow transplantation outcome

Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia.

We retrospectively analyzed the effect of HLA mismatching (HLA-A, -B, -C, -DRB1, -DQB1) with molecular typing on transplantation outcome for 301 patients with acquired severe aplastic anemia (SAA) who received an unrelated BM transplant through the Japan Marrow Donor Program. Additional effect of HLA-DPB1 mismatching was analyzed for 10 of 10 or 9 of 10 HLA allele-matched pairs (n = 169). Of th...

Towards selective HLA mismatching in clinical transplantation.

In this issue, Kosmoliaptsis et al. (1) describe a new algorithm to determine the immunogenicity of a mismatched human leukocyte antigen (HLA) alloantigen with respect to the humoral immune response. Both in organ and hematopoietic stem-cell transplantation, the best transplant results are obtained with fully HLA-matched donor recipient combinations. However, because of the enormous polymorphis...

TRANSPLANTATION Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia

1Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan; 2Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan; 4Children’s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan; 5Kanagawa Children’s Hospital...

The relevance and impact of MICA allele mismatching and MICA antibodies on renal transplantation outcome

Bone Marrow Transplantation in Thalassemia (Part 2)

During the last two decades conventional therapy has improved the prognosis of thalassemia. However, despite such improvement it still remains a progressive disease with treatment-related complications such as hepatitis, liver fibrosis, and cardiac disease. Bone marrow transplantation (BMT) can prevent or delay progression of the aforementioned complications. The importance of clinical research...